The altar is in a pentagonal apse decorated by paintings by Tintoretto, who is buried in the church.

The church was erected by the Humiliati in the mid-10th century, under design by Tiberio da Parma, who is buried in the interior. The church lay on weak foundations and in 1399 a restoration project was undertaken. The façade, built in 1460-1464, has sloping sides and is in brickwork, divided in three parts by two pilasters. Further restoration was completed in 1869. The sculpture on the facade is by Nicolò di Giovanni Fiorentino and Antonio Rizzo.